Table 8: Oral Antihistamine Doses for Cats

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Drug Name Dose
Hydroxyzine 5–10 mg/cat (NOT mg/kg) q 12 hr1
Cetirizine 5–10 mg/cat (NOT mg/kg) q 24 hr2
Chlorpheniramine 2–4 mg/cat (NOT mg/kg) q 12 hr2
Cyproheptadine 2 mg/cat (NOT mg/kg) q 12 hr2
Clemastine 0.68 mg/cat (NOT mg/kg) q 12 hr2
Loratadine 2.5–5 mg/cat (NOT mg/kg) q 24 hr1
Fexofenadine 30–60 mg/cat (NOT mg/kg) q 24 hr3
Amitriptyline 2.5–7.5 mg/cat (NOT mg/kg) q 12 hr1
Diphenhydramine 2-3 mg/kg q 12 hr2
  1. Plumb DC. Plumb’s Veterinary Drug Handbook. 9th ed. Wiley-Blackwell;2018.
  2. Miller WH, Griffin GE, Campbell KL. Muller & Kirk’s Small Animal Dermatology. 7th ed. St. Louis:Elsevier;2013.
  3. Diesel A. Feline allergy: symptomatic treatments. In: Noli C, Foster A, Rosenkrantz W, eds. Veterinary Allergy. West Sussex (UK):John Wiley and Sons;2014.

The 2023 AAHA Management of Allergic Skin Diseases in Dogs and Cats Guidelines are generously supported by Hill’s Pet Nutrition, Merck Animal Health, and Zoetis.

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