Table 1: Antipruritic and Anti-inflammatory Medications for Dogs
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Drug Name |
Oclacitinib1 |
Lokivetmab2 |
Cyclosporine3 |
Glucocorticoids4 |
---|---|---|---|---|
Mode of action |
JAK-STAT inhibitor that blocks signaling from proinflammatory and pruritogenic cytokines |
Caninized monoclonal antibody that neutralizes the pruritogenic cytokine IL-31 |
Calcineurin inhibitor that modulates T-cell function |
Influences gene expression of proinflammatory cytokines |
Administration |
PO q 12 hr up to 14 days, then reduce to q 24 hr |
SC injection at veterinary office q 4-8 wk |
PO q 24 hr |
PO q 12-24 hr with taper |
Time to onset |
Hours |
Hours to 3 days |
4-6 wk |
Hours |
Age |
>1yr |
Any |
>6 mo |
Any |
Weight |
>3 kg |
Any |
>1.8 kg |
Any |
Health restrictions |
History of demodicosis |
None |
History of neoplasia |
Congestive heart failure |
Adverse reactions |
Vomiting |
Vomiting |
Vomiting |
Polyuria/ polydipsia |
JAK-STAT, Janus kinase signal transducers and activators of transcription; PO, orally; SC, subcutaneously.
- Apoquel (oclacitinib tablet). Package insert. Zoetis, 2020.
- Cytopoint. Package insert. Zoetis, 2015.
- Atopica (cyclosporine capsules). Package insert. Elanco, 2020.
- Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. The Vet Jour. 2016;207:29–37.