References

  1. Rucinsky R, Cook A, Haley S, et al. AAHA diabetes management guidelines for dogs and cats. J Am Anim Hosp Assoc 2010;46(3):215–24.
  2. Davison LJ, Ristic JM, Herrtage ME, et al. Anti-insulin antibodies in dogs with naturally occurring diabetes mellitus. Vet Immunol Immunopathol 2003;91(1):53–60.
  3. Goossens MM, Nelson RW, Feldman EC, et al. Response to insulin treatment and survival in 104 cats with diabetes mellitus (1985-1995). J Vet InternMed 1998;12(1):1–6.
  4. Bloom CA, Rand J. Feline diabetes mellitus: clinical use of long-acting glargine and detemir. J Feline Med Surg 2014;16(3):205–15.
  5. Caney SM. Management of cats on Lente insulin: tips and traps. Vet Clin North Am Small Anim Pract 2013;43(2):267–82.
  6. Hess RS, Kass PH, Ward CR. Breed distribution of dogs with diabetes mellitus admitted to a tertiary care facility. J Am Vet Med Assoc 2000; 216(9):1414–7.
  7. Rand JS, Bobbermien LM, Hendrikz JK, et al. Over representation of Burmese cats with diabetes mellitus. Aus Vet J 1997;75(6):402–5.
  8. Gilor C, Niessen SJ, Furrow E, et al. What’s in a name? Classification of diabetes mellitus in veterinary medicine and why it matters. J Vet Intern Med 2016;30(4):927–40.
  9. Link KR, Rand JS. Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats. J Feline Med Surg 2008;10(6);583–92.
  10. Davison LJ. Diabetes mellitus and pancreatitis-cause or effect? J Small Anim Pract 2015;56(1)50–9.
  11. Scott-Moncrieff JC, Moore GE, Coe J, et al. Characteristics of commercially manufactured and compounded protamine zinc insulin. J Am Vet Med Assoc 2012;240(5):600–5.
  12. Roomp K, Rand JS. Management of diabetic cats with long-acting insulin. Vet Clin North Am Small Anim Pract 2013;43(2):251–66.
  13. Hess RS, Drobatz KJ. Glargine insulin for treatment of naturally occurring diabetes mellitus in dogs. J Am VetMed Assoc 2013;243(8):1154–61.
  14. Nelson RW, Henley K, Cole C, et al. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes mellitus in cats. J Vet InternMed 2009;23(4):787–93.
  15. Ward CR, Christiansen K, Li J, et al. Field efficacy and safety of protamine zinc recombinant human insulin in 276 dogs with diabetes mellitus. Domest Anim Endocrinol 2021;75:106575.
  16. Palm CA, Boston RC, Refsal KR, et al. An investigation of the action of Neutral Protamine Hagedorn human analogue insulin in dogs with naturally occurring diabetes mellitus. J Vet Intern Med 2009;23(1):50–5.
  17. Hoelmkjaer KM, Spodsberg EM, Bjornvad CR. Insulin detemir treatment in diabetic cats in a practice setting. J Feline Med Surg 2015;17(2):144–51.
  18. Roomp K, Rand J. Evaluation of detemir in diabetic cats managed with a protocol for intensive blood glucose control. J Feline Med Surg 2012; 14(8):566–72.
  19. Fracassi F, Corradini S, Hafner M, et al. Detemir insulin for the treatment of diabetes mellitus in dogs. J Am VetMed Assoc 2015;247(1):73–8.
  20. Martin GJ, Rand JS. Pharmacokinetic and pharmacodynamics study of caninsulin in cats with diabetes mellitus. Internal Study Report. 2000.
  21. Graham PA, Nash AS, McKellar QA. Pharmacokinetics of porcine insulin zinc suspension in diabetic dogs. J Small Anim Pract 1997;38(10):434–8.
  22. Fracassi F, Boretti FS, Sieber-Ruckstuhl NS, et al. Use of insulin glargine in dogs with diabetes mellitus. Vet Rec 2012;170(2):52.
  23. Maggiore AD, Nelson RW, Dennis J, et al. Efficacy of protamine zinc recombinant human insulin for controlling hyperglycemia in dogs with diabetes mellitus. J Vet InternMed 2012;26(1):109–15.
  24. Sparkes AH, Cannon M, Church D, et al. ISFM consensus guidelines on the practical management of diabetes mellitus in cats. J Feline Med Surg 2015;17(3):235–50.
  25. Nelson RW, Robertson J, Feldman EC, et al. Effect of the alphaglucosidase inhibitor acarbose on control of glycemia in dogs with naturally acquired diabetes mellitus. J Am VetMed Assoc 2000;216(8):1265–9.
  26. Riederer A, Zini E, Salesov E, et al. Effect of the glucagon-like peptide-1 analogue exenatide extended release in cats with newly diagnosed diabetes mellitus. J Vet Intern Med 2016;30(1):92–100.
  27. Oda H, Mori A, Lee P, et al. Characterization of the use of liraglutide for glycemic control in healthy and Type 1 diabetes mellitus suffering dogs. Res Vet Sci 2013;95(2):381–8.
  28. Gilor C, Rudinsky AJ, Hall MJ. New approaches to feline diabetes mellitus: Glucagon-like peptide-1 analogs. J Feline Med Surg 2016;18(9):733–43.
  29. Zoran DL, Rand JS. The role of diet in the prevention and management of feline diabetes. Vet Clin North Am Small Anim Pract 2013;43(2):233–43.
  30. Briggs CE, Nelson RW, Feldman EC, et al. Reliability of history and physical examination findings for assessing control of glycemia in dogs with diabetes mellitus: 53 cases (1995-1998). J Am VetMed Assoc 2000;217(1):48–53.
  31. Martin GJ, Rand JS. Comparisons of different measurements for monitoring diabetic cats treated with porcine insulin zinc suspension Vet Rec 2007;161(2):52–8.
  32. Cohen TA, Nelson RW, Kass PH, et al. Evaluation of six portable blood glucose meters for measuring blood glucose concentration in dogs. J Am Vet Med Assoc 2009;235(3):276–80.
  33. AlphaTrak 2 [product insert.] Zoetis, Parsippany, NJ. Available at: https://www.zoetisus.com/contact/pages/product_information/msds_pi/ pi/alphatrak_2.pdf. Accessed September 13, 2017.
  34. Behrend EN, Suchowersky ND, Carlson EA, et al. Comparison between glucose measurements in canine whole blood, serum, and plasma. J Vet Intern Med 2017;31:1271–2.
  35. Roomp K, Rand J. Rebound hyperglycaemia in diabetic cats. J Feline Med Surg 2016;18(8):587–96.
  36. Fleeman LM, Rand JS. Evaluation of day-to-day variability of serial blood glucose concentration curves in diabetic dogs. J Am Vet Med Assoc 2003;222(3):317–21.
  37. Ristic JM, Herrtage ME, Walti-Lauger SM, et al. Evaluation of a continuous glucose monitoring system in cats with diabetes mellitus. J Feline Med Surg 2005;7(3):153–62.
  38. Casella M, Wess G, Hassig M, et al. Home monitoring of blood glucose concentration by owners of diabetic dogs. J Small Anim Pract 2003;44(7): 298–305.
  39. Van de Maele I, Rogier N, Daminet S. Retrospective study of owners’ perception on home monitoring of blood glucose in diabetic dogs and cats. Can Vet J 2005;46(8):718–23.
  40. Alt N, Kley S, Haessig M, et al. Day-to-day variability of blood glucose concentration curves generated at home in cats with diabetes mellitus. J Am VetMed Assoc 2007;230(7):1011–7.
  41. Corradini S, Pilosio B, Dondi F, et al. Accuracy of a flash glucose monitoring system in diabetic dogs. J Vet Intern Med 2016;30(4):983–8.
  42. Shoelson AM, Mahony OM, Pavlick M. Complications associated with a flash glucose monitoring system in diabetic cats. J Feline Med Surg 2021; 23(6):557–62.
  43. Shea EK, Hess RS. Validation of a flash glucose monitoring system in outpatient diabetic cats. J Vet Intern Med 2021;35(4):1703–12.
  44. Malerba E, Cattani C, Del Baldo F, et al. Accuracy of a flash glucose monitoring system in dogs with diabetic ketoacidosis. J Vet Intern Med 2020;34(1):83–91.
  45. Behrend EN, Tapia J, Welles EG, et al. Evaluation of a conventional urine glucose test strip method for detection of glucosuria in dogs and cats [abstract]. J Vet Intern Med 2008;22:790a.
  46. Greco DS, Broussard JD, Peterson ME. Insulin therapy. Vet Clin North Am Small Anim Pract 1995;25(3):677–89.
  47. Miller E. Long-term monitoring of the diabetic dog and cat: clinical signs, serial blood glucose determinations, urine glucose and glycated blood proteins. Vet Clin North Am Small Anim Pract 1995;25(3):571–84.
  48. Crenshaw KL, Peterson ME, Heeb LA. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. J Vet InternMed 1996;10(6):360–4.
  49. Caney SM. Pancreatitis and diabetes in cats. Vet Clin North Am Small Anim Pract 2013;43(2);303–17.
  50. Behrend E. Canine hyperadrenocorticism. In: Feldman ED, Nelson RW, Reusch CE, et al, eds. Canine and Feline Endocrinology. 4th ed. St. Louis: Elsevier; 2015:403–5.
  51. Valentin SY. Clinical findings, diagnostic test results, and treatment outcome in cats with spontaneous hyperadrenocorticism: 30 cases. J Vet Intern Med 2014;28(2):481–7.
  52. Niessen SJ, Petrie G, Gaudiano F, et al. Feline acromegaly: an underdiagnosed endocrinopathy? J Vet InternMed 2007;21(5):899–905.
  53. Berg RI, Nelson RW, Feldman EC, et al. Serum insulin-like growth factor-1 concentration in cats with diabetes mellitus and acromegaly. J Vet InternMed 2007;21(5):892–8.
  54. Mooney C. Canine hyperthyroidism. In: Ettinger SJ, Feldman EC, Cote E, eds. Textbook of Veterinary Internal Medicine. 8th ed. St. Louis: Elsevier; 2017:1731–42.
  55. O’Neill DG, Gostelow R, Orme C, et al. Epidemiology of diabetes mellitus among 193,435 cats attending primary-care veterinary practices in England. J Vet Intern Med 2016;30(4):964–72.
  56. German AJ, Hervera M, Hunter L, et al. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol 2009;37(4):214–26.
  57. Keith K, Nicholson D, Rogers D. Accuracy and precision of low-dose insulin administration using syringes, pen injectors, and a pump. Clin Pediatr (Phila) 2004;43(1):69–74.
These guidelines are supported by a generous educational grant from
Boehringer Ingelheim Animal Health USA Inc., and Merck Animal Health.